Adiposity, Adult Weight Change, and Postmenopausal Breast Cancer Risk
نویسندگان
چکیده
منابع مشابه
Adult weight change and risk of postmenopausal breast cancer.
CONTEXT Endogenous hormones are a primary cause of breast cancer. Adiposity affects circulating hormones, particularly in postmenopausal women, and may be a modifiable risk factor for breast cancer. OBJECTIVE To assess the associations of adult weight change since age 18 years and since menopause with the risk of breast cancer among postmenopausal women. DESIGN, SETTING, AND PARTICIPANTS Pr...
متن کاملAssociations between weight in early adulthood, change in weight, and breast cancer risk in postmenopausal women.
BACKGROUND Adult weight is positively associated with postmenopausal breast cancer but few studies have investigated whether there are associations with weight and body mass index (BMI) in early adulthood, or subsequent weight change. METHODS A total of 14,441 postmenopausal women from the Melbourne Collaborative Cohort Study (MCCS) were followed for 16.5 years (mean) and 668 incident breast ...
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Phytoestrogens are defined as plant substances that are structurally or functionally similar to estradiol. We report the associations of two major phytoestrogens, genistein and enterolactone, with breast cancer risk, using urinary specimens collected 1-9 years before breast cancer was diagnosed. The subjects were 88 breast cancer cases and 268 controls, selected from a cohort of postmenopausal ...
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The detoxification enzyme sulfotransferase1A1 (SULT1A1) is implicated in the inactivation of estrogens and the activation of promutagens and procarcinogens. SULT1A1 activity varies among individuals, and this difference in phenotype is, in part, controlled by genetic polymorphism (Arg-->His in codon 213). It is hypothesized that the His allele contributes to the risk of postmenopausal breast ca...
متن کاملPostmenopausal testosterone therapy and breast cancer risk.
BACKGROUND Testosterone therapy is being increasingly used in the management of postmenopausal women. However, as clinical trials have demonstrated a significantly increased risk of breast cancer with oral combined estrogen-progestin therapy, there is a need to ascertain the risk of including testosterone in such regimens. OBJECTIVE Evaluation of experimental and epidemiological studies perta...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2007
ISSN: 0003-9926
DOI: 10.1001/archinte.167.19.2091